TABLE 3.
MICs for P. gingivalis wild-type, galE, and galE-c strains
| Antibiotic | MIC (μg/ml)a for:
|
||
|---|---|---|---|
| 33277 (wild type) | galE strain | galE-c strain | |
| Benzylpenicillin | 0.011 ± 0.0023 | 0.0047 ± 0.0012b | 0.0073 ± 0.0012 |
| Oxacillin | 0.10 ± 0.020 | 0.053 ± 0.010b | 0.084 ± 0.017 |
| Ampicillin | <0.016 | <0.016 | <0.016 |
| Cefotaxime | 0.0067 ± 0.0012 | 0.002 ± 0.00b | 0.006 ± 0.002c |
| Ceftriaxone | <0.002 | <0.002 | <0.002 |
| Imipenem | 0.084 ± 0.035 | 0.024 ± 0.0080b | 0.043 ± 0.018 |
| Tetracycline | 0.042 ± 0.0087 | 0.037 ± 0.0087 | 1.7 ± 0.29d |
| Erythromycin | <0.016 | >256e | <0.016 |
| Clindamycin | <0.016 | >256e | <0.016 |
| Kanamycin | >256 | >256 | >256 |
| Tobramycin | >256 | >256 | >256 |
| Vancomycin | 12 ± 4 | 1.8 ± 0.29b | 4 ± 0c |
a
Values are shown as means ± standard deviations.
b
The galE strain had significant difference in sensitivity to the indicated antibiotic compared to the wild-type 33277.
c
The galE-c strain had significant difference in sensitivity to the indicated antibiotic compared to the ΔgalE strain.
d
Resistance was dependent on insertion of tetQ.
e
Resistance was dependent on insertion of ermF.