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. 2006 Oct 6;92(1):185–191. doi: 10.1529/biophysj.106.093559

FIGURE 10.

FIGURE 10

Inhibition effects of Cu2+ and Zn2+ on Aβ40 induced DNA condensation. 15 μM DNA was incubated with 1 μM Aβ40 in the presence or absence of 1 μM metal ions. Aβ signal was subtracted respectively; CD spectra were measured at different incubation time and the proportions of undisturbed DNA were determined using the ellipticity at 250 nm. DNA with Aβ40 (solid squares); DNA with Aβ40 in the presence of Cu2+ (circles); DNA with Aβ40 in the presence of Zn2+ (upper triangles); and DNA alone (open squares).