TABLE 1.

Original and revised parameter bounds

	Original bounds		U87ΔEGFR (revised)		U87WT (revised)
Cell line	LB	UB	LB	UB	LB	UB
D × 10−4 (cm2/day)	0.1	2.0	0.1	2.0	0.1	2.0
vi (cm/day)	0	0.10	0	0.015	0.010	0.10
s × 106 cells/(cm2 day)	0.01	10	0.17	0.69	0.70	6.5
g (1/day)	0	0.30	0	0.30	.04	0.30

The model has led to tighter estimates (in bold) for v_i, s, and g than were previously known. LB indicates a lower bound and UB indicates an upper bound. The choice of the original bounds is explained in Parameter Estimation and Parameter Optimization. The revised bounds were based on Fig. 6. The bounds were chosen to be where the χ² error was <1.