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Model of A488-IgE and diI-C18 orientation and location within the plasma membrane in the absence (A) and presence (B) of IgE receptor cross-linking. Ordered regions of the membrane are indicated by high concentrations of cholesterol, sphingomyelin, glycosphingolipids, and glycerophospholipids. Upon receptor cross-linking, these domains cluster to nucleate a larger, functional domain.
