Table 3.
Treatment-related * nonhematologic toxicities (worst by patient) (n = 18 patients).
| Grade ** | |||||||
|
| |||||||
| Toxicity | 1 | 2 | 3 | 4 | 5 | Total | %pts |
|
| |||||||
| Flu-like symptoms | |||||||
| Fever | 1 | — | — | — | — | 1 | (5.6) |
| Fatigue | 5 | 5 | 1 | — | — | 11 | (61.1) |
| Rigors, chills | 4 | — | — | — | — | 4 | (22.2) |
| Gastrointestinal | |||||||
| Anorexia | 6 | 3 | — | — | — | 9 | (50.0) |
| Constipation | — | 2 | — | — | — | 2 | (11.1) |
| Diarrhea | 7 | 6 | 2 | — | — | 15 | (83.3) |
| Dysphagia | 2 | — | — | — | — | 2 | (11.1) |
| Mouth dryness | 1 | — | — | — | — | 1 | (5.6) |
| Gastritis | — | — | 1 | — | — | 1 | (5.6) |
| Nausea | 6 | 4 | 2 | — | — | 12 | (66.7) |
| Salivary gland changes | 2 | — | — | — | — | 2 | (11.1) |
| Stomatitis | 1 | — | — | — | — | 1 | (5.6) |
| Taste disturbance | 6 | — | — | — | — | 6 | (33.3) |
| Vomiting | 4 | 3 | — | — | — | 7 | (38.9) |
| Hemorrhage | |||||||
| Melena/GI bleeding | 1 | — | — | — | — | 1 | (5.6) |
| Hematuria | — | 1 | — | — | — | 1 | (5.6) |
| Infection | |||||||
| Infection w/o neutropen | — | 1 | — | — | — | 1 | (5.6) |
| Pain | |||||||
| Abdominal pain | 1 | 1 | — | — | — | 2 | (11.1) |
| Headache | 1 | 1 | — | — | — | 2 | (11.1) |
| Myalgia | 2 | — | — | — | — | 2 | (11.1) |
| Dermatology | |||||||
| Alopecia | 3 | — | — | — | — | 3 | (16.7) |
| Dry skin | — | 1 | — | — | — | 1 | (5.6) |
| Injection site reaction | 1 | — | — | — | — | 1 | (5.6) |
| Rash/desquamation | 1 | — | — | — | — | 1 | (5.6) |
| Any | 17 | 14 | 6 | 0 | 0 | 18 | (100.0) |
*Considered by investigator to be “possibly” or “definitely” related to protocol treatment.
**Toxicity graded according to NCI Common Toxicity Criteria Version 2.0.