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. 2006 Sep 29;188(23):8145–8152. doi: 10.1128/JB.01011-06

FIG. 1.

FIG. 1.

B. anthracis IsdC. (A) The Bacillus anthracis isd-like locus contains eight open reading frames: a sortase (srtB), isdC, secreted putative hemophores (isdX1 and isdX2), an iron transporter complex (isdE, -E2, and -F), and a monooxygenase (isdG). (B) Alignment of the amino acid sequences of B. anthracis isdC (BAS4444; Ba-IsdC), S. aureus IsdC (AAW38020; Sa-IsdC), and L. monocytogenes Lmo2186. The arrow indicates the predicted signal peptide cleavage site for B. anthracis IsdC. The closed bar, solid line, and dashed line indicate the proposed sortase cleavage motif (NPKTG for B. anthracis IsdC), hydrophobic domain, and positively charged tail of cell wall sorting signals, respectively. The highest degree of sequence similarity is within the NEAT domain (IsdC amino acids 32 to 146 [open bar]). Absolutely conserved amino acids are indicated below the alignment. The black dots indicate conservation of polarity, charge, or hydrophobicity.