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. 2006 Sep 22;188(23):8033–8043. doi: 10.1128/JB.01159-06

FIG. 1.

FIG. 1.

ytxAB locus encodes a putative ADP-ribosylating toxin. (A) Diagram of the arrangement of the ytxAB genes in the sapA-pspF intergenic region of Y. enterocolitica strain JB580v (8081). (B) CLUSTALW alignment of the YtxA protein with the catalytic subunit of pertussis toxin (PtxA; GenBank accession number P04947). The signal sequences (predicted for YtxA) are underlined. Identical, strongly similar, and similar residues are indicated by vertical lines, colons, and periods, respectively, between the sequences. Three conserved sequences characteristic of ADP-ribosyltransferases, including the catalytic glutamic acid residue, are indicated by boldface type (10, 16, 33). Residues important for full ADP-ribosyltransferase activity of PtxA are indicated by bullets below the sequence. Cysteine residues that form a disulfide bond in PtxA are indicated by arrows below the sequence.