TABLE 1.
Susceptibility testing results of N. meningitidisisolatesa
Bacterial isolate/site of isolation | Symptom(s) | Age/sex | Penicillin
|
Ceftriaxone
|
Cefotaxime
|
Nalidixic acid
|
Ciprofloxacin
|
Chloramphenicol
|
Antibiotic therapy | No. of daysb | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MIC | ZD | MIC | ZD | MIC | ZD | MIC | ZD | MIC | ZD | MIC | ZD | |||||
CNBC1/blood | Fever for 4 days with rash, altered sensorium | 5 yr/M | 1.5 | 35 | 1.5 | 47 | 1.5 | 48 | 128 | 6 | 0.125 | 40 | 0.50 | 37 | Ceftriaxone given at admission (day 0), chloramphenicol added on day 4 | 7 |
CNBC2/blood | Not known | 5 mo/F | 2.0 | 6 | 8 | 19 | >32 | 20 | 64 | 6 | 1.5 | 33 | 0.75 | 33 | Patient refused to be admitted, no antibiotic history available | History not available |
CNBC3/blood | Fever for 5 days with rash | 12 yr/M | 0.125 | 36 | 1.5 | 47 | 4 | 47 | 64 | 6 | 1.0 | 38 | 1.5 | 29 | Ceftriaxone given at admission (for 10 days) | 3 |
CNBC4/blood | Fever with diarrhea and dehydration | 4.5 yr/M | >32 | 6 | 0.25 | 46 | 0.50 | 48 | 64 | 6 | 1.5 | 34 | 8 | 12 | Ceftriaxone given at admission (for 6 days) | 6 |
CNBC5/CSF | Neck stiffness for 4 days with fever and vomiting | 6 yr/M | >32 | 6 | 6 | 19 | >32 | 15 | 0.047 | 18 | 0.094 | 30 | >256 | 6 | Ceftriaxone given at admission (day 0), chloramphenicol added on day 5 | 15 |
CNBC6/blood | Fever for 2 days with rash, vomiting for 1 day | 4.5 yr/F | 0.094 | ND | 1.5 | ND | 16 | ND | >256 | ND | 1.5 | ND | 12 | ND | Crystalline penicillin given at admission (day 0), ceftriaxone added on day 4 | 14 |
CNBC7/blood | Not known | 7 mo/M | 6.0 | ND | 3 | ND | 8 | ND | >256 | ND | 6 | ND | 128 | ND | Patient refused to be admitted, no antibiotic history available | History not available |
CNBC8/blood | Fever for 2 days with rash for 1 day | 10 mo/M | 0.25 | ND | 1.0 | ND | 4 | ND | >256 | ND | 2 | ND | 12 | ND | Ceftriaxone given at admission | 5 |
CSF, cerebrospinal fluid; ZD, zone diameter; ND, not determined; M, male; F, female. MIC values are given in micrograms per milliliter. Zone diameters are given in millimeters. Resistant/nonsusceptible readings are in boldface.
Number of days after starting antibiotic treatment to become afebrile.