FIG. 3.

DHPLC patterns of gyrA genes of the 109 clinical isolates when M. tuberculosis H37Rv was used as a reference strain. Patterns A, B, and C are shown as examples (details are shown in Fig. 4). W, H37Rv wild type. When M. tuberculosis Erdman was used as a reference strain, A, B, and C were changed to A1, B1, and C1, respectively. W1 indicates the M. tuberculosis Erdman wild type. Isolates (MIC less than 2 μg/ml) that harbored only the codon 95 ACC natural polymorphism with no other mutation in gyrA QRDRs showed the wild-type pattern C1.