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. 2006 Dec 15;20(24):3453–3463. doi: 10.1101/gad.1487506

Figure 1.

Figure 1.

AurA is a novel tumor suppressor gene. (A,A′) Wild-type (A) and aurA8839 (A′) larval central brain regions at 96 h ALH were stained with the NB markers Mira (red) and Insc (green); DNA staining is in blue in all panels. (B) Schematic representation of AurA domains and mutated sites for aurA8839, aurA14641, and aurA17961. (C,C′) AurA is undetectable in aurA8839 mutant larval NBs. AurA in wild-type metaphase NBs (C) is localized to both centrosomes, but is undetectable in aurA8839 metaphase NBs (C′). (D) Quantification of wild-type and aurA8839 central brain NB numbers from 24- to 96-h-ALH. n = 20 per time point per genotype. (E,E′) aur8839 larval brain (E′) can grow to a massive size compared with wild-type brains (E). Arrows point to the brain lobes.