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. 2006 Dec 15;20(24):3453–3463. doi: 10.1101/gad.1487506

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Copyright © 2006, Cold Spring Harbor Laboratory Press

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Figure 5. — AurA acts upstream of Numb to suppress tumor formation. (A–E) Numb acts as a tumor suppressor during larval brain development. (A′,B′) NB MARCM clones marked by CD8-GFP in third instar larval brains. Most cells in numb¹⁵ clones express Dpn (B) but very few cells express Elav (D), whereas in wild-type clones usually only a single cell (the NB) expresses Dpn (A) and most cells express Elav (C). (E) Quantification of the number of cells per clone in wild-type and numb¹⁵ clones. (F–G) Overexpression of Numb (nb)-GFP suppresses the NB overproliferation phenotype in aurA⁸⁸³⁹ brains. Overexpression of Numb-GFP using wor-Gal4 in aurA⁸⁸³⁹ mutant background (wor > nb-GFP;aurA⁸⁸³⁹) reduces brain size (F′) compared with the control wor-Gal4, aurA⁸⁸³⁹ (F) at 120 h ALH, and the NB number is also significantly reduced (G; n = 20 per genotype per time point).