Table 3.
A | Progression with age of lung function | B | Comparison of progression between genetic groups | C | Comparison of progressions within groups in relation to ΔF508(2) * | D | delta of Power analysis 0.8 | ||||||
Slopes within groups | Intercept at age 6 to 8 yrs mean comparison | Slope differences (age range 6 to 18 yrs) | |||||||||||
F-value | sign. | F-value | sign. | mean diff. | sign. | ||||||||
FRCpleth | ΔF508(2) | 0.151 | 1.117 | n.s. | 3.979 | 0.008 | |||||||
3905insT/ΔF | 0.215 | 1.057 | 0.048 | 0.09154 | |||||||||
R553X/ΔF | 0.165 | 0.120 | n.s. | 0.09969 | |||||||||
LCI | ΔF508(2) | 0.247 | 5.077 | 0.002 | 0.491 | n.s. | |||||||
3905insT/ΔF | 0.291 | 1.865 | 0.006 | 0.200854 | |||||||||
R553X/ΔF | 0.278 | 0.307 | n.s. | 0.236018 | |||||||||
VTG | ΔF508(2) | 0.198 | 3.372 | 0.019 | 6.499 | 0.0001 | |||||||
3905insT/ΔF | 0.233 | 1.036 | 0.011 | 0.113801 | |||||||||
R553X/ΔF | 0.256 | 0.065 | n.s. | 0.128347 | |||||||||
sReff | ΔF508(2) | 0.405 | 0.849 | n.s. | 10.043 | 0.0001 | |||||||
3905insT/ΔF | 0.549 | 1.297 | n.s. | 0.305402 | |||||||||
R553X/ΔF | 0.741 | 3.298 | 0.039 | 0.328812 | |||||||||
FEV1 | ΔF508(2) | -0.185 | 4.542 | 0.004 | 13.066 | 0.0001 | |||||||
3905insT/ΔF | -0.216 | 2.502 | 0.009 | 0.16809 | |||||||||
R553X/ΔF | -0.466 | 0.431 | n.s. | 0.18238 | |||||||||
FEF50 | ΔF508(2) | -0.439 | 1.774 | n.s. | 14.255 | 0.0001 | |||||||
3905insT/ΔF | -0.738 | 1.011 | n.s. | 0.30235 | |||||||||
R553X/ΔF | -1.029 | 2.952 | 0.002 | 0.32759 | |||||||||
Misc | -0.354 |
* adjusted for multiple comisons according Bonferroni