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. 2006 Dec 12;5(1):e2. doi: 10.1371/journal.pbio.0050002

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© 2007 van der Pluijm et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Spearman's r correlation of 16-, 96- and 130-wk-old mice with 15-d-old Csb^m/m/Xpa^−/− mice, where −1.0 is a perfect negative (inverse) correlation, 0.0 is no correlation, and +1.0 is a perfect positive correlation.

(B) Similarities between significantly overrepresented biological processes. Note that in both Csb^m/m/Xpa^−/− and naturally aged mice, transcriptional changes were mostly associated with metabolic processes.

(C) Correlation in significant expression changes of genes associated with the GH/IGF1 axis and oxidative metabolism in the livers of Csb^m/m/Xpa^−/− and naturally aged (96- and 130-wk-old) mice. An extensive overview is listed in Tables S3 and S4.