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A nestin-Psen1 transgene rescues the cerebral hemorrhages but not the caudal defects in the Psen1-/- embryo. (A-C) E18.5 wild-type (A), Psen1-/- (B)embryos and an embryo with the nestin-Psen1 transgene on the Psen1-/-background (C). The Psen1-/- embryo has an abnormal tail region (arrow) and a cerebral hemorrhage (arrowhead). By contrast, the embryo with the nestin-Psen1 transgene on the Psen1-/- background still exhibits the caudal defects (arrow) but no cerebral hemorrhages.
