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Predicted model of claudin-19, with four transmembrane domains, two extracellular loops, and intracellular termini. The first loop is characterized by the claudin-specific amino acid motif W-GLW-C-C. The Spanish/Hispanic mutation G20D is localized in the first transmembrane domain, the Swiss mutation Q57E affects a residue located between the two cysteines of the W-GLW-C-C motif, and the Turkish mutation L90P resides in the second transmembrane domain.
