Figure 4. .
Power, localization, and interpretation for a range of disease models. Each point on the X-axis corresponds to a suite of 50 studies. Each of the disease parameters is varied between suites, whereas the other parameters are held at “default” values of GRR(Aa)=2, GRR(AA)=2×GRR(Aa)-1, q=0.04, and ncc=2,000. All studies are sampled from the constant population with the full ascertainment tSNP set. A, Probability of an experimentwise significant signal within 100 kb of the causative SNP (calculated as the proportion of studies in each suite that meet this criterion). B, Probability that the association peak is within 100 kb of the causative SNP. C, Estimated causative-allele frequency versus true frequency q.