TABLE 1.
emb-4 suppresses the 0AC-Egl defect caused by lin-12(d) alleles
| Genotype | Egg-laying competent (non-Egl)/total (%) |
|---|---|
| A. emb-4 mutations reduce the activity of lin-12(d) alleles in the AC/VU decision | |
| N2 | >1000 scored (100) |
| lin-12(n302) | >1000 scored (0) |
| lin-12(n302); emb-4(sel) | 88/104 (84) |
| lin-12(n302); emb-4(qm31)a | 6/41 (15) |
| lin-12(n302); emb-4(hc60) | 6/118 (5) |
| lin-12(n950) | >1000 scored (0) |
| lin-12(n950); emb-4(sel) | 92/218 (42) |
| lin-12(n950); emb-4(qm31) | 0/65 (0) |
| lin-12(n950)/lin-12(0)b | 44/143 (31) |
| lin-12(n950)/lin-12(0); emb-4(sel)b | 77/77 (100) |
| lin-12(n950)/lin-12(0); emb-4(qm31)b | 37/63 (59) |
| B. emb-4(0) alleles fail to complement emb-4(sel) for suppression of lin-12(n302) 0AC-Egl defect | |
| lin-12(n302) | >1000 scored (0) |
| lin-12(n302); emb-4(sel)/+ | 1/39 (3) |
| lin-12(n302); emb-4(qm31)/+ | 0/17 (0) |
| lin-12(n302); emb-4(sel)/emb-4(qm31) | 34/42 (81) |
| lin-12(n302); emb-4(hc60)/+ | 0/18 (0) |
| lin-12(n302); emb-4(sel)/emb-4(hc60) | 10/13 (77) |
a
Of 107 animals, 41 had living progeny; the rest were sterile.
b
Actual genotype on chromosome III is lin-12(n950)/unc-36(e251) lin-12(n941).