TABLE 2.
Selected groups of genes induced in the cdc53-1 and cdc34-2 mutants
| Biological process (based on gene ontology) | P-value | Genes | Genes in input cluster/genes in category | Fold enrichmenta | Cdc34/SCF target(s) regulating this process |
|---|---|---|---|---|---|
| Amino acid metabolism (GO:0006520) | 1.011e-10 | GDH3, HIS4, LYS20, ARO3, MET32, ARO10, SER3, STR3, ARG4, ARO9, LYS1, ARG3, MET3, CPA2, MET14, MET1, ECM40, MET2, LYS9, ARG1, HIS3, CPA1, ICL2, MET16 | 24/140 | 4.8 | Gcn4, Met4 |
| Sulfur utilization (GO:0006791) | 5.288e-08 | MET10, MET3, ECM17, MET14, MET1, MET16 | 6/8 | 20.9 | Met4 |
| Vitamin metabolism (GO:0006766) | 2.857e-05 | TKL2, RIB5, BNA1, BNA2, TH111, BNA5, SNO1, SNZ1, SNZ2, THI21 | 10/57 | 4.9 | Gcn4 |
| Sodium transport (GO:0006814) | 0.003759 | ENA5, ENA2 | 2/3 | 18.6 | Gcn4 |
| Cell–cell adhesion (GO:0016337) | 0.00734 | AGA2, MUC1 | 2/4 | 13.9 | Gcn4 |
| Sporulation (GO:0030435) | 0.007634 | UBC5, SPO71, SPS1, PRB1, SHC1, SGA1, SPS19, SPO21 | 8/80 | 2.8 | ? |
| Purine base metabolism (GO:0006144) | 0.01 | ADE1, MTD1, ADE2 | 3/13 | 6.4 | Gcn4 |
| Cell wall organization and biogenesis (GO:0007047) | 0.03079 | ECM13, YDL222C, TIR1, GSC2, ECM17, PIR3, KTR2, ECM40, PKH2 | 9/122 | 2.1 | ? |
| Heavy metal ion homeostasis (GO:0030006) | 0.03227 | PCA1, SIT1, ISU2, 1SU1 | 4/34 | 3.3 | ? |
| Signal transduction of mating signal (GO:0007330) | 0.03769 | AFR1, MFA1, STE3 | 3/21 | 4.0 | Tec1, Ste7 |
Table was generated by analyzing the combined list of genes induced in the cdc53-1 and cdc34-2 data sets using Funspec (Robinson et al. 2002).
a
Fold enrichment is the percentage of category genes induced in the mutant/percentage of category genes found in the genome.