Table 1. BIAcore kinetic analysis of binding of mabs to s-IGF-1R.

The results generated are from three separate runs and the average of k_a, k_d and K_D for each mAb is shown. Results are means (±S.D.) from three independent experiments. The dissociation constant K_D=k_d/k_a.

mAb	ka (1/Ms) (×105)	kd (1/s) (×10−4)	KD (M) (×10−9)
7C2	0.66 (±1.8)	0.31 (±0.2)	0.5 (±1.6)
9E11	0.8 (±0.2)	1.7 (±0.1)	2.1 (±0.4)
αIR-3	1.0 (±0.3)	1.2 (±0.5)	1.3 (±0.5)