Table 2. Summary of epitopes of murine anti-IGF-1R mAbs and their effect on IGF-I binding to the IGF-1R.

MAbs	Epitope (residues and domain)	Effect on IGF-I binding
αIR-3	223–274 (CR)	Inhibits [13]
24-31	283–440 (CR-L2)	No effect [27]
24-55	440–586 (L2-Fn3α)	Inhibits [27]
24-60	184–283 (CR)	Inhibits [27]