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. 2006 Dec 11;401(Pt 1):49–55. doi: 10.1042/BJ20060870

Figure 3. PRL induces SERCA 2b over-expression by JAK2 pathway.

Figure 3

(A) Western blot analysis of PRL (100 ng/ml) induced over-expression of SERCA 2b. AG490 (50 μM) prevents PRL-induced over-expression of SERCA 2b. (B) Western blot analysis of calreticulin expression. PRL (100 ng/ml) did not induce the over-expression of calreticulin. Treatment with 50 μM AG490 before the addition of 100 ng/ml PRL had no effect. (C) Western blot analysis of JAK2 and phospho-JAK2 expression. PRL (100 ng/ml) induced the over-phosphorylation of this JAK2. CTL, control; PRL, 100 ng/ml PRL; AG490+PRL, treatment with 50 μM AG490 before the addition of 100 ng/ml PRL.