Table 1. Effect of blocking NF-κB activation on baseline and SAM-/MTA-mediated inhibition of BHMT expression.

BHMT mRNA levels were determined using real-time PCR after HepG2 cells were infected with adenoviruses carrying empty vector or IκBSR for 12 h and treated with SAM (5 mM) or MTA (1 mM) for another 12 h. Results represent means±S.E.M. from four to eight experiments. *P<0.005 versus control, **P<0.05 versus adenoviral vector control, ***P<0.05 versus SAM or MTA.

Treatment	BHMT mRNA level (% of control)
Control	100±0
Adenoviral vector control	98±6
SAM	61±6*
MTA	30±2*
IκBSR	120±7**
+SAM	134±16***
+MTA	70±6***