Figure 1. .

Haplotype analysis with use of genetic markers at chromosomal region 5q35.2-q35.5 in a French family with HAE type III. The presence of a C or an A in the second position of codon 328 of F12 (located between D5S2111 and D5S2030) is indicated by the resulting amino acid (Thr or Lys). To avoid disclosure of carrier status of unaffected individuals, only affected individuals, obligate carriers, and founder individuals are depicted. The putative disease-associated haplotype(s) is boxed. A missing genotype is indicated by a hyphen (-). The presence of 328Lys is associated with a history of angioedema attacks.