Figure 2. .

Thr328Lys mutation in factor XII in patients with HAE type III. a, Sequencing profiles showing part of exon 9 (nucleotide positions 1027–1037, according to cDNA sequence gi:9961354) in an affected female (III:2) from the French family (left panel) and in a control individual (right panel). b, Schematic picture of the primary structure of the factor XII protein, with known functionally important domains indicated as boxes. Amino acid ranges covering functional domains are given below the primary structure. The location of the Thr328Lys mutation in the proline-rich domain is indicated by an arrow.