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. 2005 Sep;167(3):901–912. doi: 10.1016/S0002-9440(10)62061-5

Figure 3.

Figure 3

B-lymphocyte numbers are decreased and T-lymphocyte numbers are increased in the periphery of ApoE−/−/PDGF-B−/− chimeras. A: Representative FACS analyses are shown of B220 staining of splenocytes from 30-week-old PDGF-B+/+ and −/− chimeras gated for lymphocytes. B: B-cell numbers are decreased in spleens of ApoE−/−/PDGF-B−/− chimeras, although total lymphocyte numbers are comparable for the two chimera groups. Flow analysis of B220 staining of three independent transplant (TX) experiments at 30 weeks are shown (n = 3 per group, P < 0.05). C: The decrease in B cells is associated with an increase in T cells in ApoE−/−/PDGF-B−/− chimeras (n = 3 per group, P < 0.01). CD4 and CD8 staining was performed with the same splenocyte samples as in B.