Figure 1.

Decreased acquisition of metastatic ability of tumor cells grown in gp91^phox−/− mice. QR-32 tumor cells (A–C, 1 × 10⁵) were subcutaneously (s.c.) co-implanted with gelatin sponge, and B16BL6 cells (D–F, 4 × 10⁵ in 0.05 ml) were injected into the hind footpad (i.f.), respectively, of WT mice and gp91^phox−/− mice (A and D). The metastasis incidence (B and E) and number of colonies per lung (C and F) were counted. *P < 0.001 versus WT. The actual number of incidences is indicated above each bar (number of mice with tumor or metastasis/number of mice tested).