Table 2.
Experimental Metastatic Abilities of Tumor Cells Intravenously Injected into gp91phox−/− and WT Mice
| Mice | Cell line | Number of lung metastatic nodules | Lung weight (g) | Metastatic incidence (%) |
|---|---|---|---|---|
| WT | QRsP-11 | 144.1 ± 11.8 | 1.2 ± 0.3 | 8/8 (100) |
| gp91phox−/− | QRsP-11 | 138.0 ± 19.1 | 1.0 ± 0.2 | 9/9 (100) |
| WT | B16BL6 | 111.5 ± 49.7 | 0.4 ± 0.1 | 10/10 (100) |
| gp91phox−/− | B16BL6 | 97.8 ± 43.2 | 0.4 ± 0.2 | 13/13 (100) |
QRsP-11 fibrosarcoma (1 × 106 cells) and B16BL6 melanoma (4 × 105 cells) were injected via the tail vein. They were sacrificed for necropsy on days 21 and 14, respectively. Data represent the mean ± SD.