Figure 1-6913.

Immunolocalization of RLN2 and LGR7. Human goiter (A) and Graves’ disease (not shown) tissues were devoid of RLN2. By contrast, RLN2 immunoreactivity was present in human papillary (PTC; B), follicular (FTC; D), and dedifferentiated, anaplastic thyroid carcinoma (UTC; F). H: Using a previously characterized rabbit polyclonal antiserum to human LGR7,8 weak immunoreactivity for LGR7 was detected in thyrocytes of normal human thyroid tissues. Irrespective of pTNM classification of the tumor tissues investigated, immunoreactive LGR7 was up-regulated in PTC (J), FTC (L), and UTC (N) tissues (Table 1). Sections incubated with a rabbit nonimmune serum as control were devoid of immunostaining as demonstrated by the representative insets (C, E, G, I, K, M, O). Original magnifications: ×200 (A–C, E, H–K, M); ×400 (D, F, G, L, N, O).