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Morphometric analysis. Glomerular area (A) and volume (B) were smaller in mice on CE2 (triangles) than in animals receiving placebo (Pla, squares) (P < 0.005) or sham-operated mice. Intermittent E2 replacement (IE2, inverted triangles) or tamoxifen (Tam, circles) did not reduce either of these parameters. Percentage of vascular space (C) increased with CE2 and Tam therapy. Each point on the graph represents an individual mouse. *P < 0.05, **P < 0.005.
