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. 2006 Aug;169(2):372–387. doi: 10.2353/ajpath.2006.060043

Figure 3-6944.

Figure 3-6944

Renal interstitial fibrosis caused by ischemia-reperfusion injury is dependent on CX3CR1. All analyses were performed in three independent experiments with four to five animals in each experiment. A and B: Histopathological analysis. Trichrome-stained outer medulla from CX3CR1-deficient (A) and wild-type (B) mice 14 days after injury. Images are from one representative animal of each genotype. C: Kinetics of fibrotic change: histochemical analysis. Fibrotic change was quantitated in trichrome-stained sections of outer medulla under the conditions shown. Values are mean ± SEM. D: Kinetics of fibrotic change: biochemical analysis. Hydroxyproline content of the left kidney was quantitated for the conditions shown. Values are mean ± SEM. −/−, CX3CR1 knockout mice; +/+, wild-type control mice; sham, sham-operated wild-type mice tested 24 hours after surgery. *P < 0.05 comparing CX3CR1-deficient mice versus wild-type mice at the same time point. Original magnifications, ×320.