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Protein C levels. Citrated plasma was collected at the times indicated, and protein C antigen levels were determined by ELISA as described in the Materials and Methods. Normal (100%) was defined using pooled normal baboon plasma. Challenge dose in CFU/kg: 105 to 106 (▿, n = 2); 107 (□, n = 3); 108 (•, n = 3); and 109 (▴, n = 3). Significant differences from the low-dose challenge (105 to 106 CFU/kg) were determined: *P < 0.05, **P < 0.01.
