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. 2006 Sep;169(3):815–822. doi: 10.2353/ajpath.2006.060037

Figure 2.

Figure 2

ET-1 promotes skin inflammation after UVB irradiation via ETA. A: UVB-induced (250 mJ/cm2) ear swelling in C57BL/6 mice pretreated with the ET receptor antagonists BQ-123 (ETA,10−4M), BQ-788 (ETB,10−4M), or vehicle (0.9% NaCl, 200 μl i.v.) (n = 11 to 21/group). B: Inflammation-associated neutrophil recruitment into the ears of BQ-123-, BQ-788-, or vehicle-pretreated mice on day 8 after UVB irradiation as assessed by measuring MPO activity. Data are expressed as percentage of MPO in vehicle-treated mice (n = 16 to 17/group). Data pooled from three independent experiments. All data shown as means ± SEM. **P = <0.01, ***P = <0.005 versus baseline values.