Figure 6.

ET-1-mediated, UVB-induced skin inflammation is dependent on ET_A expressed by MCs. A: UVB-induced (250 mJ/cm²) swelling in MC-engrafted (gray bars) and MC-deficient (white bars) ears 5 days after irradiation. Data pooled from four independent experiments (n = 22 to 33/group). B: UVB-induced (250 mJ/cm²) swelling in MC-engrafted (left) and MC-deficient (right) ears of Kit^W/Kit^W-v mice pretreated with BQ-123 (10⁻⁴ M, 200 μl i.v.) or vehicle 1 hour before irradiation. Data pooled from three independent experiments (n = 8 to 11/group). A and B: All data shown as means ± SEM. *P = <0.05, **P = < 0.01, ***P = <0.005. n.s., not significant.