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. 2006 Sep;169(3):943–953. doi: 10.2353/ajpath.2006.051319

Figure 2.

Figure 2

S/L mice show elevated IL-4 and IL-10 responses and delayed development of L. donovani-specific IFN-γ responses compared to L mice. The left graphs show cytokine levels in supernatants of spleen cell cultures stimulated with ConA or formalin-fixed L. donovani amastigote antigen (FLAA). The right graphs show serum cytokine levels (mean levels in naïve mouse sera: IFN-γ, 0.393 ± 0.089; IL-4, 0.882 ± 0.017; IL-10, 1.450 ± 0.066 ng/ml). Data represent the mean ± SE cytokine levels from three mice per group for the splenocyte responses and five mice per group for the serum cytokines at each time point. FLAA-specific and serum IFN-γ levels were significantly higher in L mice (open circle) than in S/L mice (filled square) at +2 weeks (P < 0.02). Serum IFN-γ levels were significantly higher in S/L mice than in L mice at +4 weeks (P < 0.02). IL-4 and IL-10 splenocyte responses were significantly higher in S/L than in L mice (IL-4: P < 0.02 and < 0.05 at +4 and +8 weeks, respectively; IL-10: P = 0.02 and < 0.05 at +2 and +4 weeks, respectively). Serum IL-4 levels were significantly higher in SL than in L mice at +4 weeks (P < 0.05).