Figure 5.

The proportion of mature parenchymal L. donovani granulomas in the liver increases progressively in L mice but not in S/L mice. Foci of infection were examined in 50 adjacent fields (×400 magnification) of H&E-stained liver tissue and recorded as L. donovani-infected Küpffer cells, immature or mature granulomas. The data shown are the mean percentages of mature granulomas ± SE from the S/L (filled square) and L (open circle) groups and is representative of two separate experiments. Percentages of mature granulomas were significantly higher in L mice than S/L mice at +4 and +8 weeks (n = 5 mice per group at each time point; *P < 0.05; **P < 0.002).