Figure 6.

The failure of L. donovani control in S/L mice is not characterized by heavy accumulation of amastigotes within individual foci. Amastigotes, visualized by staining as described in Figure 4, were counted in individual foci and the frequencies of foci containing differing numbers of amastigotes determined. The data are based on examination of 50 adjacent fields (×1000 magnification, n = 5 mice) and is representative of two separate experiments. Data refer to L. donovani foci in the parenchyma of L mice (open bars), the parenchyma of S/L mice (shaded bars), and the egg granulomatous tissue of S/L mice (black bars). *Significantly higher than in the parenchyma of S/L mice (P < 0.01) and L mice (P < 0.02). **Significantly higher than in the parenchyma of S/L mice (P < 0.01) and L mice P < 0.001).