Figure 6.

The reduced NK1.1⁺CD3⁺ cell numbers, decreased IFN-γ and CXCR3 expression levels in E-selectin^−/− mice and E-selectin^−/− mice treated with anti-P-selectin mAb. BAL fluid was analyzed by flow cytometry 4 days after bleomycin administration. Total number of NK1.1⁺CD3⁺ cells (A), intracellular IFN-γ expression level of CD3⁺ cells (B), CXCR3 expression levels of CD3⁺ cells (C), and representative dot plots of CXCR3⁺CD3⁺ cell frequency (D). Percentages of CXCR3⁺CD3⁺ cells are shown in the upper right quadrants. These data are representative of three independent experiments.