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Gram stains of GAS during invasive soft tissue infection. Depicted are gram-stained skin tissue sections from mice infected with WT GAS strain MGAS5005 (B, C) and ΔcovR mutant strain JRS950 (E, F). Also shown are the external pathologies for the same animals infected with WT (A) and ΔcovR mutant (D). IHC analyses of biopsies from the same animals are depicted in Figure 5, B (WT) and D (Mutant), respectively. Original magnifications: ×40 (B, E); ×1000 (C, F).
