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. 2006 Oct;169(4):1238–1250. doi: 10.2353/ajpath.2006.051136

FIGURE 4.

FIGURE 4

Inhibitory effects of gefitinib on liver fibrosis of the PCK rat. A and B: Representative photographs of the picrosirius red staining of the liver sections (A: PCK rats, untreated. B: PCK rats, treated with gefitinib, 10 mg/kg). C: Histological assessment of the liver fibrosis. The picrosirius red-stained area was determined in individual liver sections. D: Measurement of collagen content in the liver. Gefitinib (10 mg/kg) significantly reduced the collagen content in the livers of the PCK rats. E: RT-PCR analysis of CTGF and TGF-β1 mRNA expression in the whole liver. Results of semiquantitative analysis of the gel images are shown in F and G. Data represent the mean ± SD in four sets. **P < 0.01. *P < 0.05. Original magnifications, ×20.