Skip to main content
. 2006 Oct;169(4):1167–1182. doi: 10.2353/ajpath.2006.051314

FIGURE 5.

FIGURE 5

Wound closure analysis in diabetic mice treated with AdCMV.PlGF and in controls. A: Topical application of AdCMV.PlGF accelerates wound closure in diabetic mice with respect to saline and AdCMV.LacZ treatments, approximating the timing of closure observed in untreated healthy controls. The wound area is significantly reduced in AdCMV.PlGF-treated diabetic mice compared with AdCMV.LacZ- and saline-treated diabetic mice but not with untreated healthy animals. *P < 0.05; **P < 0.01; ***P < 0.005, AdCMV.PlGF versus AdCMV.LacZ. B: Representative pictures of diabetic wounds treated either with AdCMV.PLGF or with AdCMV.LacZ taken immediately after wounding (day 0) and at different times after injury, illustrating the increased reduction of the wound area following PlGF gene transfer compared with LacZ gene transfer.