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Mutations at the first RUNX site decrease L1Hs transcription. (A) Promoter activities of the wild-type and mutant L1Hs 5′UTRs in 143B cells are normalized to that of pGL-RP-PacI (RLU, relative luciferase units). Wild-type sequences for the three RUNX sites are shown. (B) Promoter activities of the wild-type and mutant L1Hs 5′UTRs in HeLa cells (n = 9).
