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. 2003 Aug 15;31(16):4941–4949. doi: 10.1093/nar/gkg666

Table 2. Effects of ErmC′ mutations on erythromycin resistance.

ErmC′ variant Erythromycin MIC (mg/l)
Negative control (empty pUC18) 80
wt >2560
T108A 640–1280
R112A 1280
R112D 640–1280
K133A 1280
R134A 80
R140A 640–1280
K197A >2560
N192A 2560
M196A >2560
N200A >2560
E202A 2560
K204A 2560
K205A 2560
K209A >2560
Clustera 2560
Δ182–244 80
Δ193–203 80
Δ207–219 80

Δ, indicated deletion.

aCluster, K197A/N200A/E202A/K204A/K205A.