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. 2003 Aug 15;31(16):4828–4835. doi: 10.1093/nar/gkg668

Table 2. Protein domains disproportionately distributed among alternatively spliced genes.

Domain name Domain ID InterPro ID No. of constitutively spliced loci with this domain No. of alternatively spliced loci with this domain No. of constitutively spliced loci without this domain No. of alternatively spliced loci without this domain P-value
Cadherin domain pfam00028 IPR002126 50 50 3566 882 0
Cadherin repeats smart00112 IPR002126 47 43 3569 889 0
Protein tyrosine phosphatase, catalytic domain smart00194 IPR000242 18 21 3598 911 0.000004
Protein tyrosine phosphatase, catalytic domain motif smart00404 IPR003595 20 21 3596 911 0.000011
Protein-tyrosine phosphatase pfam00102 IPR000242 22 22 3594 910 0.000011
B-box zinc finger pfam00643 IPR000315 12 16 3604 916 0.000021
Caspase, interleukin-1 beta converting enzyme (ICE) homologs smart00115 IPR002398 2 9 3614 923 0.000023
ICE-like protease (caspase) p10 domain pfam00655 IPR002138 2 9 3614 923 0.000023
ICE-like protease (caspase) p20 domain pfam00656 IPR001309 2 9 3614 923 0.000023
Domain in SPla and the RYanodine receptor smart00449 IPR003877 6 12 3610 920 0.000028
Ankyrin repeats smart00248 IPR002110 5 11 3611 921 0.00004
B-box-type zinc finger smart00336 IPR000315 12 15 3604 917 0.000061
Dual specificity phosphatase, catalytic domain smart00195 IPR000340 12 15 3604 917 0.000061
Fibronectin type III domain smart00060 IPR003961 16 17 3600 915 0.000071
Ank repeat pfam00023 IPR002110 14 15 3602 917 0.000179
Dual specificity phosphatase pfam00782 IPR000340 18 17 3598 915 0.000181
Ring finger smart00184 IPR001841 16 16 3600 916 0.000183
SPRY domain pfam00622 IPR003877 11 13 3605 919 0.000269
Somatotropin hormone family pfam00103 IPR001400 0 5 3616 927 0.000358
Zinc-binding domain seen in both chromatinic and cytoskeletal proteins LOAD_zz   0 5 3616 927 0.000358
Serine/threonine protein kinases, catalytic domain smart00220 IPR002290 46 28 3570 904 0.000406
Tyrosine kinase, catalytic domain smart00219 IPR001245 46 28 3570 904 0.000406
Double-stranded RNA binding motif pfam00035 IPR001159 1 6 3615 926 0.000422
Zinc finger, C3HC4 type (ring finger) pfam00097 IPR001841 16 15 3600 917 0.000459