Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1970 Jun 20;2(5711):695–698. doi: 10.1136/bmj.2.5711.695

Australian Antigen and Autoantibodies in Chronic Hepatitis

T L Vischer
PMCID: PMC1700632  PMID: 4988026

Abstract

The sera of 110 patients with chronic hepatitis and adequate controls were examined for antibodies to smooth muscle (S.M.), mitochondria (M.), and for antinuclear factors by the immunofluorescence method, and for Australia (Au(1)) antigen by a modified micro-Ouchterlony immunodiffusion technique. Twelve out of 13 patients with primary biliary cirrhosis had M. antibodies, two had antinuclear factor, and none had Au(1) in their sera. In chronic aggressive hepatitis 23·5% of the sera contained antinuclear factor, 13% S.M. antibodies, 10·5% M. antibodies, and 22% Au(1) antigen. Of the 12 patients with chronic persistent hepatitis, one had antinuclear factor, one S.M. antibodies, and three Au(1) antigen.

The most striking finding was a mutual exclusion between Au(1) antigen and M. and S.M. antibodies. None of the 33 patients with one or the other form of chronic hepatitis and M. or S.M. antibodies had Au(1) antigen; 22 out of 77 (28%) patients without such antibodies were positive.

Full text

PDF
698

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blumberg B. S., Sutnick A. I., London W. T. Australia antigen and hepatitis. JAMA. 1969 Mar 10;207(10):1895–1896. [PubMed] [Google Scholar]
  2. Doniach D., Roitt I. M., Walker J. G., Sherlock S. Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications. Clin Exp Immunol. 1966 Jul;1(3):237–262. [PMC free article] [PubMed] [Google Scholar]
  3. Doniach D., Walker J. G. A unified concept of autoimmune hepatitis. Lancet. 1969 Apr 19;1(7599):813–815. doi: 10.1016/s0140-6736(69)92072-8. [DOI] [PubMed] [Google Scholar]
  4. Fox R. A., Niazi S. P., Sherlock S. Hepatitis-associated antigen in chronic liver disease. Lancet. 1969 Sep 20;2(7621):609–612. doi: 10.1016/s0140-6736(69)90324-9. [DOI] [PubMed] [Google Scholar]
  5. Giles J. P., McCollum R. W., Berndtson L. W., Jr, Krugman S. Relation of Australia-SH antigen to the willowbrook MS-2 strain. N Engl J Med. 1969 Jul 17;281(3):119–122. doi: 10.1056/NEJM196907172810302. [DOI] [PubMed] [Google Scholar]
  6. HOTCHIN J. The biology of lymphocytic choriomeningitis infection: virus-induced immune disease. Cold Spring Harb Symp Quant Biol. 1962;27:479–499. doi: 10.1101/sqb.1962.027.001.046. [DOI] [PubMed] [Google Scholar]
  7. Johnson G. D., Holborow E. J., Glynn L. E. Antibody to smooth muscle in patients with liver disease. Lancet. 1965 Oct 30;2(7418):878–879. doi: 10.1016/s0140-6736(65)92505-5. [DOI] [PubMed] [Google Scholar]
  8. Krassnitzky O., Pesendorfer F., Wewalka F. Australia-SH-Antigen und Lebererkrankungen. Dtsch Med Wochenschr. 1970 Feb 6;95(6):249–253. doi: 10.1055/s-0028-1108445. [DOI] [PubMed] [Google Scholar]
  9. Krugman S., Giles J. P., Hammond J. Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967 May 1;200(5):365–373. doi: 10.1001/jama.200.5.365. [DOI] [PubMed] [Google Scholar]
  10. Kössling F. K., Meyer zum Büschenfelde Zur Induktion einer aktiven chronischen Hepatitis durch heterologe lösliche Leberproteine. Virchows Arch A Pathol Pathol Anat. 1968;345(4):365–376. [PubMed] [Google Scholar]
  11. Mathews J. D., Mackay I. R. Australia antigen in chronic hepatitis in Australia. Br Med J. 1970 Jan 31;1(5691):259–261. doi: 10.1136/bmj.1.5691.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Meyer zum Büschenfelde, Kössling F. K., Dietz R. Immunfluoreszenzhistologische Untersuchungen an Leberpunktaten mit markierten Organproteinen. Verh Dtsch Ges Pathol. 1969;53:325–330. [PubMed] [Google Scholar]
  13. PARONETTO F., SCHAFFNER F., POPPER H. Immunocytochemical reaction of serum of patients with hepatic diseases with hepatic structures. Proc Soc Exp Biol Med. 1961 Jan;106:216–219. doi: 10.3181/00379727-106-26291. [DOI] [PubMed] [Google Scholar]
  14. Preisig R., Gocke D., Morris T., Bradley S. E. Chronic hepatic injury following experimental viral hepatitis in the dog. Experientia. 1966 Oct 15;22(10):701–702. doi: 10.1007/BF01902457. [DOI] [PubMed] [Google Scholar]
  15. Prince A. M. Relation of Australia and SH antigens. Lancet. 1968 Aug 24;2(7565):462–463. doi: 10.1016/s0140-6736(68)90512-6. [DOI] [PubMed] [Google Scholar]
  16. RUBIN E., SCHAFFNER F., POPPER H. PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS. Am J Pathol. 1965 Mar;46:387–407. [PMC free article] [PubMed] [Google Scholar]
  17. WALKER J. G., DONIACH D., ROITT I. M., SHERLOCK S. SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS. Lancet. 1965 Apr 17;1(7390):827–831. doi: 10.1016/s0140-6736(65)91372-3. [DOI] [PubMed] [Google Scholar]
  18. Wright R., McCollum R. W., Klatskin G. Australia antigen and smooth muscle antibody in acute and chronic hepatitis. Gut. 1969 Dec;10(12):1052–1052. [PubMed] [Google Scholar]
  19. Wright R., McCollum R. W., Klatskin G. Australia antigen in acute and chronic liver disease. Lancet. 1969 Jul 19;2(7612):117–121. doi: 10.1016/s0140-6736(69)92437-4. [DOI] [PubMed] [Google Scholar]
  20. Zuckerman A. J., Taylor P. E., Almeida J. D. Presence of particles other than the Australia-SH antigen in a case of chronic active hepatitis with cirrhosis. Br Med J. 1970 Jan 31;1(5691):262–264. doi: 10.1136/bmj.1.5691.262. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES