Table 5.
GOstat results. Representation of different GO functional categories as determined by the GOstat program [48].
Woodfine replication markers 1 | ||||
Function | Islands | > 1.75 | 1.75–1.5 | < 1.5–1.25 |
Apoptosis (programmed cell death) | over | over | ||
Frizzled-2 (WNT) signaling pathway | over | |||
Intracellular ligand-gated ion channel activity | over | |||
Transmembrane receptor protein tyrosine kinase activity | over | |||
Transmembrane receptor protein tyrosine phosphatase activity | over | |||
G-protein coupled receptor activity | under | under | over | |
Rhodopsin-like receptor activity | under | under | over | |
G-protein coupled receptor protein signaling pathway | under | under | under | over |
Olfactory receptor activity | under | under | over | |
Sensory perception of smell | under | under | over | |
Proteasome complex (sensu Eukaryota) | over | |||
Cation-transporting ATPase activity | over | |||
Positive regulation of signal transduction | over | |||
Lipid biosynthesis | over | |||
Lipid metabolism | over | |||
Intracellular protein transport | over | |||
Receptor signaling protein activity | over | |||
Regulation of transcription factor activity | over | |||
Protein binding2 | over | under | ||
Positive regulation of cellular process | over | under | ||
Intracellular membrane-bound organelle | over | under | ||
Cell surface receptor linked signal transduction | under | under | over | |
Transmembrane receptor activity | under | over | ||
Neurophysiological process | under | over | ||
Nucleosome assembly | under | over | ||
DNA binding | over | |||
DNA metabolism | over | |||
Antigen processing endogenous antigen via MHC class I2 | over | |||
MHC class I protein complex2 | over | |||
MHC class I receptor activity2 | over | |||
Calcium-mediated signaling | over | |||
Calcium ion binding | under | |||
Carbohydrate binding | under | |||
Muscle contraction | under | |||
Integral to membrane | under | over | ||
Phosphoric ester hydrolase activity | over | |||
Organismal physiological process | over | |||
Cell communication | over | |||
Glutamate signaling pathway | over | |||
Keratin filament | over | |||
Sensory perception of taste | over | |||
Positive regulation of cellular metabolism | under |
1- Replication timing ratios determined by Woodfine et al. [18, 19].
2- Indicates functional categories overrepresented in genes associated with Woodfine et al. ([18, 19]) timing markers.