Table 5.
GOstat results. Representation of different GO functional categories as determined by the GOstat program [48].
| Woodfine replication markers 1 | ||||
| Function | Islands | > 1.75 | 1.75–1.5 | < 1.5–1.25 |
| Apoptosis (programmed cell death) | over | over | ||
| Frizzled-2 (WNT) signaling pathway | over | |||
| Intracellular ligand-gated ion channel activity | over | |||
| Transmembrane receptor protein tyrosine kinase activity | over | |||
| Transmembrane receptor protein tyrosine phosphatase activity | over | |||
| G-protein coupled receptor activity | under | under | over | |
| Rhodopsin-like receptor activity | under | under | over | |
| G-protein coupled receptor protein signaling pathway | under | under | under | over |
| Olfactory receptor activity | under | under | over | |
| Sensory perception of smell | under | under | over | |
| Proteasome complex (sensu Eukaryota) | over | |||
| Cation-transporting ATPase activity | over | |||
| Positive regulation of signal transduction | over | |||
| Lipid biosynthesis | over | |||
| Lipid metabolism | over | |||
| Intracellular protein transport | over | |||
| Receptor signaling protein activity | over | |||
| Regulation of transcription factor activity | over | |||
| Protein binding2 | over | under | ||
| Positive regulation of cellular process | over | under | ||
| Intracellular membrane-bound organelle | over | under | ||
| Cell surface receptor linked signal transduction | under | under | over | |
| Transmembrane receptor activity | under | over | ||
| Neurophysiological process | under | over | ||
| Nucleosome assembly | under | over | ||
| DNA binding | over | |||
| DNA metabolism | over | |||
| Antigen processing endogenous antigen via MHC class I2 | over | |||
| MHC class I protein complex2 | over | |||
| MHC class I receptor activity2 | over | |||
| Calcium-mediated signaling | over | |||
| Calcium ion binding | under | |||
| Carbohydrate binding | under | |||
| Muscle contraction | under | |||
| Integral to membrane | under | over | ||
| Phosphoric ester hydrolase activity | over | |||
| Organismal physiological process | over | |||
| Cell communication | over | |||
| Glutamate signaling pathway | over | |||
| Keratin filament | over | |||
| Sensory perception of taste | over | |||
| Positive regulation of cellular metabolism | under | |||
1- Replication timing ratios determined by Woodfine et al. [18, 19].
2- Indicates functional categories overrepresented in genes associated with Woodfine et al. ([18, 19]) timing markers.