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The biochemical severity of disease-associated mutations, differences among species, and nonsynonymous mutations
| Type | Number of observations | Grantham Distance | |
| Average | Std. Error | ||
| Disease-associated | 7,966 | 92.06 | 0.57 |
| Nonsynonymous SNPs | 4,022 | 64.95 | 0.65 |
| Differences among species | 148,558 | 66.61 | 0.19 |
1 -Grantham measure [19] was used to quantify the biochemical distance between amino acids.
