Abstract
Circulating platelets of cats infused with 14C-dopamine take up the amine against a concentration gradient, with maximal concentration occurring 10 min after infusion. 58%, of the platelet-bound radioactive dopamine was localized in a subcellular fraction rich in 5-hydroxytryptamine (5-HT) storage organelles. The results support earlier work with human platelets showing in vitro dopamine uptake by normal platelets, and in vivo accumulation in parkinsonian patients treated with L-dopa.
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Selected References
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