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. 1968 Nov;34(3):630–638. doi: 10.1111/j.1476-5381.1968.tb08492.x

Effects of prostaglandins E1 and E2 on human, guinea-pig and rat isolated small intestine

A Bennett, K G Eley, G B Scholes
PMCID: PMC1703473  PMID: 5726791

Abstract

1. Prostaglandins E1 and E2 contracted the longitudinal muscle of human, guinea-pig and rat isolated ileum.

2. The site of action varied with the species. In the rat and in some strips of human tissue prostaglandin appeared to have only a direct action on or in the muscle cells. In the other strips of human tissue and in guinea-pig ileum the prostaglandins seemed to stimulate both the intrinsic cholinergic nerves and the muscle cells.

3. In contrast to the longitudinal muscle, the circular muscle of human, guinea-pig and rat isolated ileum was usually inhibited by prostaglandin, apparently by an action directly on the muscle cells.

4. Prostaglandins may play a part in the control of intestinal motility.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGSTROM S., ELIASSON R., von EULER U., SJOVALL J. Some biological effects of two crystalline prostaglandin factors. Acta Physiol Scand. 1959 Mar 31;45:133–144. doi: 10.1111/j.1748-1716.1959.tb01685.x. [DOI] [PubMed] [Google Scholar]
  2. Bennett A. A pharmacological investigation of human isolated ileum. Nature. 1965 Dec 25;208(5017):1289–1291. doi: 10.1038/2081289a0. [DOI] [PubMed] [Google Scholar]
  3. Bennett A., Eley K. G., Scholes G. B. Effect of prostaglandins E1 and E2 on intestinal motility in the guinea-pig and rat. Br J Pharmacol. 1968 Nov;34(3):639–647. doi: 10.1111/j.1476-5381.1968.tb08493.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bennett A., Friedmann C. A., Vane J. R. Release of prostaglandin E-1 from the rat stomach. Nature. 1967 Dec 2;216(5118):873–876. doi: 10.1038/216873a0. [DOI] [PubMed] [Google Scholar]
  5. Bennett A., Misiewicz J. J., Waller S. L. Analysis of the motor effects of gastrin and pentagastrin on the human alimentary tract in vitro. Gut. 1967 Oct;8(5):470–474. doi: 10.1136/gut.8.5.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bennett A., Murray J. G., Wyllie J. H. Occurrence of prostaglandin E2 in the human stomach, and a study of its effects on human isolated gastric muscle. Br J Pharmacol Chemother. 1968 Feb;32(2):339–349. [PubMed] [Google Scholar]
  7. Bennett A., Whitney B. A pharmacological investigation of human isolated stomach. Br J Pharmacol Chemother. 1966 Aug;27(2):286–298. doi: 10.1111/j.1476-5381.1966.tb01663.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Coceani F., Pace-Asciak C., Volta F., Wolfe L. S. Effect of nerve stimulation on prostaglandin formation and release from the rat stomach. Am J Physiol. 1967 Oct;213(4):1056–1064. doi: 10.1152/ajplegacy.1967.213.4.1056. [DOI] [PubMed] [Google Scholar]
  9. DAY M., VANE J. R. An analysis of the direct and indirect actions of drugs on the isolated guinea-pig ileum. Br J Pharmacol Chemother. 1963 Feb;20:150–170. doi: 10.1111/j.1476-5381.1963.tb01306.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gershon M. D. Effects of tetrodotoxin on innervated smooth muscle preparations. Br J Pharmacol Chemother. 1967 Mar;29(3):259–279. doi: 10.1111/j.1476-5381.1967.tb01958.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. HARRY J. The action of drugs on the circular muscle strip from the guinea-pig isolated ileum. Br J Pharmacol Chemother. 1963 Jun;20:399–417. doi: 10.1111/j.1476-5381.1963.tb01478.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HORTON E. W., MAIN I. H. A COMPARISON OF THE BIOLOGICAL ACTIVITIES OF FOUR PROSTAGLANDINS. Br J Pharmacol Chemother. 1963 Aug;21:182–189. doi: 10.1111/j.1476-5381.1963.tb01514.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Khairallah P. A., Page I. H., Türker R. K. Some properties of prostaglandin E1 action on muscle. Arch Int Pharmacodyn Ther. 1967 Oct;169(2):328–341. [PubMed] [Google Scholar]

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