Abstract
1. Prostaglandins E1 and E2 contracted the longitudinal muscle of human, guinea-pig and rat isolated ileum.
2. The site of action varied with the species. In the rat and in some strips of human tissue prostaglandin appeared to have only a direct action on or in the muscle cells. In the other strips of human tissue and in guinea-pig ileum the prostaglandins seemed to stimulate both the intrinsic cholinergic nerves and the muscle cells.
3. In contrast to the longitudinal muscle, the circular muscle of human, guinea-pig and rat isolated ileum was usually inhibited by prostaglandin, apparently by an action directly on the muscle cells.
4. Prostaglandins may play a part in the control of intestinal motility.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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