Skip to main content
PMC home page
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1964 Oct;23(2):[420], 421-432. doi: 10.1111/j.1476-5381.1964.tb01598.x

Production of an anti-inflammatory substance at a site of inflammation

B V Robinson, J M Robson
PMCID: PMC1704107  PMID: 14228142

Abstract

The anti-inflammatory effect of various substances was measured in rats implanted with cotton wool pellets. Injection or implantation of irritant materials decreased the deposition of granulation tissue on the pellets. As the amount of irritant material increased there was a corresponding decrease in the amount of tissue deposited on the pellets. There is evidence that this could not be explained by a limit to the amount of granulation tissue available within the body, and competition for it between the cotton pellets and the implanted substances. An alternative hypothesis that an anti-inflammatory substance is produced at the site of irritation (the site of implantation of the irritant substance, such as polyester sponges) was investigated. The evidence obtained supports this hypothesis. Inflammatory exudate, squeezed from polyester sponges which had been implanted subcutaneously in the backs of adrenalectomized rats. The substance responsible for this effect is probably not a steroid, and is not normally present in the plasma of adrenalectomized animals. There is, however, some (although not conclusive) evidence that it is present in the plasma of animals in which sponges have been implanted. It does not appear to be produced by incubation in vitro of plasma with sponge. The significance of these observations is discussed.

Full text

PDF
422

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CYGIELMAN S., ROBSON J. M. THE EFFECT OF IRRITANT SUBSTANCES ON THE DEPOSITION OF GRANULATION TISSUE IN THE COTTON PELLET TEST. J Pharm Pharmacol. 1963 Dec;15:794–797. doi: 10.1111/j.2042-7158.1963.tb12882.x. [DOI] [PubMed] [Google Scholar]
  2. DIPASQUALE G., GIRERD R. J. Anti-inflammatory properties of lyophilized inflammatory exudates. Am J Physiol. 1961 Dec;201:1155–1158. doi: 10.1152/ajplegacy.1961.201.6.1155. [DOI] [PubMed] [Google Scholar]
  3. DIPASQUALE G., GIRERD R. J., BEACH V. L., STEINETZ B. G. ANTIPHLOGISTIC ACTION OF GRANULOMA POUCH EXUDATES IN INTACT OR ADRENALECTOMIZED RATS. Am J Physiol. 1963 Dec;205:1080–1082. doi: 10.1152/ajplegacy.1963.205.6.1080. [DOI] [PubMed] [Google Scholar]
  4. HIGHTON T. C. The effect of sera from patients with rheumatoid arthritis on carrageenin granuloma pouches, skin wounds and weight gain in rats. Br J Exp Pathol. 1963 Apr;44:137–144. [PMC free article] [PubMed] [Google Scholar]
  5. LADEN C., BLACKWELL R. Q., FOSDICK L. S. Anti-inflammatory effects of counterirritants. Am J Physiol. 1958 Dec;195(3):712–718. doi: 10.1152/ajplegacy.1958.195.3.712. [DOI] [PubMed] [Google Scholar]
  6. MEIER R., SCHULER W., DESAULLES P. Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch Cortisone. Experientia. 1950 Dec 15;6(12):469–471. doi: 10.1007/BF02154110. [DOI] [PubMed] [Google Scholar]
  7. PETERSON R. E. Metabolism of adrenocorticosteroids in man. Ann N Y Acad Sci. 1959 Oct 14;82:846–853. doi: 10.1111/j.1749-6632.1960.tb44966.x. [DOI] [PubMed] [Google Scholar]
  8. SPECTOR W. G., WILLOUGHBY D. A. The activation by irritants of slow-contracting substances, and their relation to the vascular changes of inflammation in the rat. J Pathol Bacteriol. 1962 Oct;84:391–403. doi: 10.1002/path.1700840213. [DOI] [PubMed] [Google Scholar]
  9. SPECTOR W. G., WILLOUGHBY D. A. The demonstration of the role of mediators in turpentine pleurisy in rats by experimental suppression of the inflammatory changes. J Pathol Bacteriol. 1959 Jan;77(1):1–17. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES