Abstract
The elimination of theophylline is decreased after vaccination against influenza. In three patients receiving 200 mg of oxtriphylline (equivalent to 128 mg of theophylline) every 6 hours by mouth the serum theophylline levels rose after vaccination, and in four healthy volunteers given the same dose of oxtriphylline 24 hours after vaccination the half-life of theophylline increased by an average of 122%. Two of the three patients showed signs of a toxic reaction to the drug. These results suggest that the elimination of theophylline is impaired to a clinically important degree after influenza vaccination and that the resulting levels of the drug can be toxic even when conventional therapeutic doses of theophylline are given.
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Selected References
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- Chang K. C., Bell T. D., Lauer B. A., Chai H. Altered theophylline pharmacokinetics during acute respiratory viral illness. Lancet. 1978 May 27;1(8074):1132–1133. doi: 10.1016/S0140-6736(78)90305-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jatlow P. Ultraviolet spectrophotometry of theophylline in plasma in the presence of barbiturates. Clin Chem. 1975 Sep;21(10):1518–1520. [PubMed] [Google Scholar]
- Lohmann S. M., Miech R. P. Theophylline metabolism by the rat liver microsomal system. J Pharmacol Exp Ther. 1976 Jan;196(1):213–225. [PubMed] [Google Scholar]
- McCarthy J. S., Furner R. L., Van Dyke K., Stitzel R. E. Effects of malarial infection on host microsomal drug-metabolizing enzymes. Biochem Pharmacol. 1970 Apr;19(4):1341–1349. doi: 10.1016/0006-2952(70)90049-3. [DOI] [PubMed] [Google Scholar]
- Renton K. W., Mannering G. J. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents. Biochem Biophys Res Commun. 1976 Nov 22;73(2):343–348. doi: 10.1016/0006-291x(76)90713-0. [DOI] [PubMed] [Google Scholar]
- Renton K. W. The deleterious effect of Bordetella pertussis vaccine and poly(rI.rC) on the metabolism and disposition of phenytoin. J Pharmacol Exp Ther. 1979 Feb;208(2):267–270. [PubMed] [Google Scholar]
- Soyka L. F., Hunt W. G., Knight S. E., Foster R. S., Jr Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum. Cancer Res. 1976 Dec;36(12):4425–4428. [PubMed] [Google Scholar]